2Pain in your knees, ankles, and wrists
Besides the big toe, uric acid crystals can form in any joint in the body. So, severe, unexplained pain in any joint may be an indication of gout. Approximately 25 percent of gout patients develop polyarticular symptoms, which means they attack more than one joint at a time. Because gout can mimic other conditions like rheumatoid arthritis, it’s especially difficult to diagnose when it appears in multiple joints.